Form Bio Resources

Industry updates, best practices and expert perspectives on computational life sciences.

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Featured
AI, Genetic Engineering and Gene Therapy: The Next Frontier in Life Science Innovation
Artificial Intelligence
blog

AI, Genetic Engineering and Gene Therapy: The Next Frontier in Life Science Innovation

Joe Nipko, PhD

Uncover the emerging role of AI in gene therapy and how it is paving the way for groundbreaking advancements.

Featured
Form Bio and Google Team Up To Streamline Multiomics and Accelerate Precision Medicine
Bioinformatics
blog

Form Bio and Google Team Up To Streamline Multiomics and Accelerate Precision Medicine

Chris Haas

Discover how Form Bio and Google Cloud’s Multiomics Suite will empower life scientists to accelerate research, development, and pre-clinical studies in personalized medicine and gene therapies.

Featured
Leveraging AI Models To Improve Safety of Gene Therapy
Vector Design
blog

Leveraging AI Models To Improve Safety of Gene Therapy

Nick Ketz, PhD

Learn how predictive modeling can generate synthetic regulatory sequences for safer and more efficacious gene therapies.

Featured
Form Bio Applauds The White House’s New Goals and Priorities Promoting Growth of Domestic Cell and Gene Therapy Biomanufacturing
Biomanufacturing
blog

Form Bio Applauds The White House’s New Goals and Priorities Promoting Growth of Domestic Cell and Gene Therapy Biomanufacturing

Andrew Busey & Kent Wakeford

We support the commitment of the Biden-Harris Administration to address global issues through biomanufacturing innovation. Learn more.

Featured
New Study Finds Large Language Models Applied to DNA Sequences Enabled Accurate Molecular Phenotype Prediction
Vector Design
blog

New Study Finds Large Language Models Applied to DNA Sequences Enabled Accurate Molecular Phenotype Prediction

Austin Day, PhD

Recent published research is bringing us one step closer to predicting molecular phenotypes from a DNA sequence. Read this blog to learn more.

Featured
Recent Advancements in AAV Production Process for Gene Therapy Manufacturing
Biomanufacturing
blog

Recent Advancements in AAV Production Process for Gene Therapy Manufacturing

Jill Roughan, PhD

Explore the AAV production process for gene therapy manufacturing, as well as the techniques and efficiency improvements to enhance AAV payload purity.

Featured
How Are AAV Vectors Transforming Gene Therapy?
Vector Design
blog

How Are AAV Vectors Transforming Gene Therapy?

Claire Aldridge, PhD

Discover why AAV vectors are key to gene therapy success, offering precise delivery, wide clinical applications, and transformative impact in genetic disease treatment.

Featured
Accelerating AAV Gene Therapy Research with AI-assisted Biological Experiments
Artificial Intelligence
blog

Accelerating AAV Gene Therapy Research with AI-assisted Biological Experiments

Bijan Zakeri, PhD

Discover how AI-assisted biological lab experiments accelerate AAV research and de-risk vector design.

Featured
AAV Gene Therapy Product Characterization using Next-Generation Sequencing (NGS)
Artificial Intelligence
blog

AAV Gene Therapy Product Characterization using Next-Generation Sequencing (NGS)

Claire Aldridge, PhD

See how AAV product characterization can be optimized using next-generation sequencing (NGS).

Featured
Healthcare
Informed insights

How Computational Life Sciences Will Help Us Address and Advance Health Equity

Claire Aldridge, PhD

Despite significant healthcare spending, the United States sees poorer health outcomes than other countries. Learn how computational life sciences can help address this.

Featured
Cell and Gene Therapy
Informed insights

Characterizing Full, Empty, and Truncated AAV Capsids

Claire Aldridge, PhD

Industry leaders are prioritizing the improvement of the manufacturability and accessibility of gene therapies, focusing on the distinction between full and empty capsids. Gain insights from our Chief Strategy Officer.

Featured
Cell and Gene Therapy
Informed insights

What the FDA’s New Safety Draft Guidance for AAV Gene Therapies Means and How to Be Ready

Claire Aldridge, PhD

Get up to speed on the FDA's safety guidance draft that could impact clinical trials for gene therapy products. Our Chief Strategy Officer provides a framework on how to overcome potential safety issues.

Featured
Bioinformatics
Informed insights

Opportunities for Applying Today’s Computational Advances to Yesterday’s Analysis Techniques

Brandi Cantarel, PhD

Read hear to learn more about the past, present and future of bioinformatics sequence analysis.

Featured
Emerging Trends
Informed insights

Design for Manufacturing: A New Paradigm for Computational Life Sciences

Alexander Titus, PhD

With the help of computational life sciences, biotechnology is evolving. Learn how design for manufacturing design is advancing research, discovery and development processes.

Featured
Emerging Trends
Informed insights

Living in the Golden Age of Deep Learning and Life Sciences

Joe Nipko, PhD

With modern advancements in computational power and learning algorithms, we are in the golden age of deep learning in the life sciences and its applications.

Featured
Navigating Viral Vector Biomanufacturing Scale Up: An Essential Handbook
Cell and Gene Therapy
Downloads

Navigating Viral Vector Biomanufacturing Scale Up: An Essential Handbook

Viral vectors are necessary for cell and gene therapy development yet there are several barriers to high-yield production. Learn how to overcome them in our handbook.

Featured
Biological Validation Studies Report
Cell and Gene Therapy
Downloads

Biological Validation Studies Report

Form Bio's AI models accurately predict and optimize vector design outcomes. Multiple studies conducted in collaboration with independent labs demonstrate how AI supports the design of more effective and manufacturable gene therapy constructs.

Featured
An Introduction to BLAST and Sequence Alignment Tools
Computational Life Sciences
Downloads

An Introduction to BLAST and Sequence Alignment Tools

Just learning the basics of BLAST in bioinformatics? Get all the fundamentals on biology’s most widely used bioinformatics tool.

Featured
Computational Life Sciences Careers, Salaries and Resources
Careers
Downloads

Computational Life Sciences Careers, Salaries and Resources

Interested in pursuing a computational life science career? There’s a increasing need for talented computational scientists. Here’s why choosing a computational life science tech job is a good idea.

Featured
RNA-Seq Data Analysis 101: A Primer for Computational Life Scientists
Computational Life Sciences
Downloads

RNA-Seq Data Analysis 101: A Primer for Computational Life Scientists

There is no one-size-fits-all method for doing RNA-Seq, but some well-accepted guidelines exist. Learn about the best practices for RNA-Seq data analysis.

Featured
Evaluating Computational Life Sciences Platforms: 5 Dos and 5 Don'ts
Computational Life Sciences
Downloads

Evaluating Computational Life Sciences Platforms: 5 Dos and 5 Don'ts

Download our guide, to learn what you need to know about selecting a Computational Life Sciences Platform that will serve your organizations needs, today and in the future.

Featured
Comparing Form Bio Data Analysis Performance With and Without NVIDIA Clara Parabricks
Bioinformatics
Downloads

Comparing Form Bio Data Analysis Performance With and Without NVIDIA Clara Parabricks

Genetic variant detection has wide application in genomics including identifying genetic changes that drive phenotypic changes. Over the last decade several open source tools have been developed to improve the accuracy and speed of SNV/Indel variant detection. Download our case report, to learn what how accelerated versions of these tools using GPUs have been shown to reduce computational time and resources.

Featured
Public Gene Therapy Company Elevates Manufacturability of Constructs
Cell and Gene Therapy
Downloads

Public Gene Therapy Company Elevates Manufacturability of Constructs

Learn about the common challenges in rAAV modeling and production and how FORMsightAI predictively reduced the truncations that impact development cost and time-to-market.

Featured
Resilience Case Study: Accelerating AAV Vector Development with AI
Cell and Gene Therapy
Downloads

Resilience Case Study: Accelerating AAV Vector Development with AI

Form Bio and Resilience collaborate on AI-assisted molecular design for 2x increase in encapsidated full genomes.

Featured
Characterizing Drug Products with NGS
Cell and Gene Therapy
Downloads

Characterizing Drug Products with NGS

A publicly-traded gene therapy company that is developing an AAV therapeutic used Form Bio’s analytical solutions to characterize their DP to streamline the regulatory review process. Briefly, they used long-read NGS sequencing to extract comprehensive sequence data from DPs, and then utilized Form Bio’s analytical solutions to detect and quantify vector sequence variants and residual DNA.

Featured
AAV Candidate Testing & Selection—A New Solution for Accelerating Vector Design
Cell and Gene Therapy
Downloads

AAV Candidate Testing & Selection—A New Solution for Accelerating Vector Design

In silico techniques for generating and screening libraries prior to in vitro testing provides actionable insights, guiding researchers towards candidates with the highest PoS.

Featured
How a Publicly Traded Gene Therapy Company Optimized Construct Designs with FORMsightᴬᴵ
Cell and Gene Therapy
Webinars

How a Publicly Traded Gene Therapy Company Optimized Construct Designs with FORMsightᴬᴵ

Gene therapies can save lives and revolutionize medicine. But trial-and-error manufacturing consumes precious time and capital, creating risks for companies. Join Form Bio's leaders to learn how AI predicts and optimizes construct design for real-world manufacturing.

Featured
How a Publicly Traded Gene Therapy Company Optimized Construct Designs with FORMsightᴬᴵ
Cell and Gene Therapy
Webinars

How a Publicly Traded Gene Therapy Company Optimized Construct Designs with FORMsightᴬᴵ

Gene therapies can save lives and revolutionize medicine. But trial-and-error manufacturing consumes precious time and capital, creating risks for companies. Join Form Bio's leaders to learn how AI predicts and optimizes construct design for real-world manufacturing.

Featured
Data Science Meets Life Science
Emerging Trends
Webinars

Data Science Meets Life Science

Hear industry experts from NVIDIA, BCG and ElevateBio explore key challenges, opportunities and investment areas for data science and AI in life sciences, along with practical frameworks for successful implementation.

Featured
Data Science Meets Life Science
Emerging Trends
Webinars

Data Science Meets Life Science

Hear industry experts from NVIDIA, BCG and ElevateBio explore key challenges, opportunities and investment areas for data science and AI in life sciences, along with practical frameworks for successful implementation.

Featured
Explore Google's Advanced Omics AI Models
Bioinformatics
Webinars

Explore Google's Advanced Omics AI Models

Join Form Bio & Google for a scientific discussion on pivotal discoveries using some of the most popular Google Cloud Vertex AI-powered workflows.

Featured
Explore Google's Advanced Omics AI Models
Bioinformatics
Webinars

Explore Google's Advanced Omics AI Models

Join Form Bio & Google for a scientific discussion on pivotal discoveries using some of the most popular Google Cloud Vertex AI-powered workflows.

Featured
Accelerating AAV Vector Development with AI
Cell and Gene Therapy
Webinars

Accelerating AAV Vector Development with AI

In this webinar we'll unveil the latest breakthroughs in AI modeling for evaluating and optimizing vector designs to reduce discovery timelines from years to weeks! Discover how Resilience and Form Bio teamed up to apply cutting-edge in silico techniques, accelerating the vector design process, while producing a safer and more manufacturable vector.

Featured
Accelerating AAV Vector Development with AI
Cell and Gene Therapy
Webinars

Accelerating AAV Vector Development with AI

In this webinar we'll unveil the latest breakthroughs in AI modeling for evaluating and optimizing vector designs to reduce discovery timelines from years to weeks! Discover how Resilience and Form Bio teamed up to apply cutting-edge in silico techniques, accelerating the vector design process, while producing a safer and more manufacturable vector.

Featured
Introducing Form Bio
Company News
Webinars

Introducing Form Bio

Join this on-demand webinar to learn about why we started Form Bio and industry-leading team behind the scenes. Then join our Product Manager for a high-level demo of the Form Bio platform.

Featured
Introducing Form Bio
Company News
Webinars

Introducing Form Bio

Join this on-demand webinar to learn about why we started Form Bio and industry-leading team behind the scenes. Then join our Product Manager for a high-level demo of the Form Bio platform.

Featured
Cell and Gene Therapy Manufacturing: Current and Future States
Cell and Gene Therapy
Webinars

Cell and Gene Therapy Manufacturing: Current and Future States

Tune into this webinar and join Form Bio's Head of Solutions Science, Alpha Diallo, PhD and PacBio's Associate Director of Product Marketing, Elizabeth Tseng, PhD to learn about next-gen cell and gene therapy manufacturing.

Featured
Cell and Gene Therapy Manufacturing: Current and Future States
Cell and Gene Therapy
Webinars

Cell and Gene Therapy Manufacturing: Current and Future States

Tune into this webinar and join Form Bio's Head of Solutions Science, Alpha Diallo, PhD and PacBio's Associate Director of Product Marketing, Elizabeth Tseng, PhD to learn about next-gen cell and gene therapy manufacturing.

Featured
Rare Disease Day 2023: The Future of Rare Disease R+D
Cell and Gene Therapy
Webinars

Rare Disease Day 2023: The Future of Rare Disease R+D

On Rare Disease Day 2023, Form Bio joined forces with Beyond Batten Disease Foundation for a live discussion on the promise and challenges of rare disease research and development. While the world of novel therapeutics is ever evolving, there are serious hurdles to affecting life-changing care for rare disease families.

Featured
Rare Disease Day 2023: The Future of Rare Disease R+D
Cell and Gene Therapy
Webinars

Rare Disease Day 2023: The Future of Rare Disease R+D

On Rare Disease Day 2023, Form Bio joined forces with Beyond Batten Disease Foundation for a live discussion on the promise and challenges of rare disease research and development. While the world of novel therapeutics is ever evolving, there are serious hurdles to affecting life-changing care for rare disease families.

Featured
Harnessing HiFi Sequencing & AI for Enhanced Gene Therapy Design
Cell and Gene Therapy
Webinars

Harnessing HiFi Sequencing & AI for Enhanced Gene Therapy Design

Gene therapy has reached a critical point where precision is paramount. The synergy between HiFi sequencing and AI technology emerges as a transformative tool for characterizing and optimizing AAV quality. It reveals previously invisible issues that could significantly impact the safety, efficacy, and manufacturability of cell and gene therapies.

Featured
Harnessing HiFi Sequencing & AI for Enhanced Gene Therapy Design
Cell and Gene Therapy
Webinars

Harnessing HiFi Sequencing & AI for Enhanced Gene Therapy Design

Gene therapy has reached a critical point where precision is paramount. The synergy between HiFi sequencing and AI technology emerges as a transformative tool for characterizing and optimizing AAV quality. It reveals previously invisible issues that could significantly impact the safety, efficacy, and manufacturability of cell and gene therapies.

Featured
 Exploring Biological Validation Results for AI-Based in silico Techniques in AAV Gene Therapy Development
Cell and Gene Therapy
Webinars

Exploring Biological Validation Results for AI-Based in silico Techniques in AAV Gene Therapy Development

The initial lab results are in! Join Form Bio to delve into the latest biological studies, demonstrating how our AI models can accurately predict and optimize vector outcomes.‍This webinar will explore key insights that demonstrate FORMsightAI's performance:Predicting Design Problems Accurately and ReproduciblyGenerating Vector Designs That Reduce Undesirable CharacteristicsGenerating Vector Designs That Increase Desirable CharacteristicsGet a closer look at our 1 billion+ parameter LLM, trained on over 3 trillion nucleotides and how FORMsightAI predicts and optimizes key outcomes of AAV vector design.

Featured
 Exploring Biological Validation Results for AI-Based in silico Techniques in AAV Gene Therapy Development
Cell and Gene Therapy
Webinars

Exploring Biological Validation Results for AI-Based in silico Techniques in AAV Gene Therapy Development

The initial lab results are in! Join Form Bio to delve into the latest biological studies, demonstrating how our AI models can accurately predict and optimize vector outcomes.‍This webinar will explore key insights that demonstrate FORMsightAI's performance:Predicting Design Problems Accurately and ReproduciblyGenerating Vector Designs That Reduce Undesirable CharacteristicsGenerating Vector Designs That Increase Desirable CharacteristicsGet a closer look at our 1 billion+ parameter LLM, trained on over 3 trillion nucleotides and how FORMsightAI predicts and optimizes key outcomes of AAV vector design.

Case Studies

Improving AAV Manufacturability with AI/ML Simulation to Reduce Genome Truncations

Improve AAV manufacturability with AI/ML in silico techniques to identify the best performing vector design for lead candidates.

Case Studies

AI/ML Simulation is Able to Reliably and Reproducibly predict AAV Genome Truncation

AI simulation can reliably and reproducibly predict AAV genome truncation to help increase production lot yield and lower manufacturing costs.

Case Studies

AI/ML Optimization of Coding Sequences Reduces Genome Truncations in AAV Vectors

AI/ML optimization of the coding sequence (CDS) of a gene-of-interest (GOI) can de-risk AAV manufacturing by reducing partially filled AAV capsids.

Case Studies

Reducing the Risk of Immunogenicity Using an AI/ML Model

AI/ML models can reduce the immunogenicity risk of %CpG islands through sequence optimization, while maintaining a consistent %GC content.

Case Studies

Optimization of the CDS Using an AI/ML Model Outperforms an Open-Source Codon Optimization Tool by Improving Enzymatic Activity by 20%

AI/ML optimization of the coding sequence (CDS) can outperform open-source codon optimization tools by increasing mRNA expression by 24% and increasing enzymatic activity by 20%.

Case Studies

AI/ML Optimization Reduces AAV Discovery Timeline from Years to Days

AI/ML optimization can reduce AAV discovery timelines from years to days, identifying an optimal vector design quickly and resulting in 91% full capsids.