Genome editing is a rapidly growing method used in research and clinical applications. Several different editing techniques have emerged that facilitate various types of genome editing, each with its unique parameters, capabilities, and restrictions. Currently, no methods are available to guide researchers on the best technique for their specific needs. To address this gap, we developed CRISPRank, a novel computational tool that offers an end-to-end solution for designing genome editing experiments and selecting the most appropriate strategy for a desired outcome. By entering your locus-of-interest (or loci-of-interest), CRISPRank determines the sgRNAs required for each editing strategy and ranks them based on several criteria. This tool streamlines genome editing workflows, enabling scientists to quickly find a genome engineering solution that works for them.