Vector Design
Explore up to billions of possible design element combinations
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Analytical Development
Clearly understand the potential and risks of your construct
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Process Development
Smooth scale-up for higher yield and lower COGS
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Form Bio is your partner in building therapeutic development programs for the AI era.

Key steps in the drug development process where our programs help you accelerate:

Drug Candidate Design

Form helps you advance initial construct concepts forward to testable candidates that can be analyzed, compared and further optimized.

  • Optimize promoter, ITR, backbone and other elements

  • Remove reporter genes

  • Select capsids

  • Enhance codons

  • Analyze CG content

  • Analyze FTO

Candidate Testing & Selection

Form helps you get to your research grade drug faster, to test mRNA and protein expression and validate preclinical efficacy in vitro.

  • Optimize promoter, ITR, backbone and other elements

  • Remove reporter genes

  • Select capsids

  • Enhance codons

  • Analyze CG content

  • Analyze FTO

Test Manufacturing

Form helps ensure you can produce an efficacious, safe drug with high enough yield, and fully characterized.

  • Optimize promoter, ITR, backbone and other elements

  • Remove reporter genes

  • Select capsids

  • Enhance codons

  • Analyze CG content

  • Analyze FTO

Drug Validation

Form helps you confirm mRNA and protein expression and validate your therapeutic for replicating preclinical efficacy in vivo.

  • Optimize promoter, ITR, backbone and other elements

  • Remove reporter genes

  • Select capsids

  • Enhance codons

  • Analyze CG content

  • Analyze FTO

IND Enabling Studies

Form makes it easier to get critical toxicity and safety answers and to be prepared with every bit of data you’ll need for IND submission.

  • Optimize promoter, ITR, backbone and other elements

  • Remove reporter genes

  • Select capsids

  • Enhance codons

  • Analyze CG content

  • Analyze FTO

1    Drug Candidate Design2   Candidate Testing & Selection3  Test Manufacturing4   Drug Validation5   IND Enabling Studies

Featured
Program Elements

Drug Product Characterization

Detailed analysis of the manufactured drug product, including proportion of full viral genomes to non-therapeutic encapsidated species.

Multi-Candidate Comparison

Compare the safety, yield and expression of multiple candidates with with different vector design elements.

Bioreactor
Simulation

Test candidate therapeutics in silico for production output in a virtual suspension-cell bioreactor.

Gene Expression
Prediction

Analyze mRNA for transcription and translation efficiency to predict the levels of therapeutic protein production.

Immunotoxicity Analysis

Analyze the potential risks associated with CpG islands and other viral genomic patterns.

AI-powered Candidate Optimization

Leverage large language models and deep learning to rapidly analyze billions of possible versions of a therapeutic construct.

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More About Our Capabilities

Product Characterization

Fully understand constructs with automated AAV characterization reporting.

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Biomanfuacturing Simulation

Predict manufacturing results relating to truncations and other issues.

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Comparative Analysis

Compare an array of
constructs with different design characteristics to find the most promising versions.

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Generative Optimization

Enhance constructs to generate de novo designs with the best predicted yield, efficacy and safety characteristics.

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Empowering scientists  
across focus areas

HOW FORM BIO HELPS WITH

Vector Design

Rationally explore more vector design possibilities with Form Bio's AI/ML models, purposefully trained on AAV vector nucelotide sequences.

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Analytical Development

Easily characterize and analyze manufactured drug product to fully understand content, quality and potential risks.

Learn more

Process Development

Reduce your cost of goods (COGS) and optimize process development with in silico bioreactor simulations.

Learn more

Our Technology

A comprehensive tech suite built to enable Accelerated cell and gene therapy development and computational biology at scale.

Learn more about our technology and integrations
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Featured Insights

ADVANCED SOLUTION icon
INFORMED INSIGHTS
Distinguishing AAV Empty and
Fragmented Capsids
Case Study icon
Case
STudy
Machine Learning for
Cell and Gene Therapy
White Paper icon
White
Paper
Elevating Manufacturability of
Constructs with FORMsightAI
ADVANCED SOLUTION icon
INFORMED INSIGHTS

Distinguishing AAV Empty and Fragmented Capsids

An op-ed on bridging the gene therapy “accessibility gap” through manufacturing solutions to extend the reach of transformative treatments to patients worldwide.

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Case Study icon
Case STudy

Publicly Traded Gene Therapy Company Elevates Manufacturability of Constructs with FORMsightAI

Learn how a gene therapy company leveraged AI and machine learning models to increase yield, safety and efficiency of pre-clinical manufacturing.

form bio case study
White Paper icon
White Paper

Developing Machine Learning Powered Solutions for Cell and Gene Therapy Candidate Validation

Discover how AI/ML can enhance viral vector manufacturability and address the challenge of construct truncation.

form bio featured resource

Trusted by industry leaders

Trusted by Top Scientists and Organizations

Jenny Marlowe, PhD
Jenny Marlowe, PhD
Chief scientific Officer, solid biosciences

"As a Form Bio customer, we are thrilled with the uniquely valuable AI-driven insights they've contributed to our research and development efforts. By working closely with this world class team and cutting edge technology, we can clearly see that applying innovative AI solutions to pre-clinical cell and gene therapy development offers exciting potential for CGT companies' economics, market timing and ability to impact human health."

George Church, PhD
George Church, PhD
Professor, harvard medical school & MIT; Director of synthetic biology, the wyss institute

"Computer-aided design, fabrication, testing analyses and machine learning are key to the future of bioengineering in general and specifically restoration of endangered and extinct genetic diversity for keystone species in vital ecosystems. Form Bio is the software critical to pave the way."

Eriona Hysolli, PhD
Eriona Hysolli, PhD
Head of biological sciences, Colossal biosciences

"Form Bio helps Colossal's biology teams save time and maximize our research in ways we didn’t realize were possible. Having access to an incredibly easy-to-use interface coupled with Form’s deep bench of bioinformatics and data science expertise is core to our workflows and how we fulfill our ambitious research objectives."

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See how Form can empower you

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