Transforming Genetic Medicine & Genome Engineering with AI

Genetic Medicine

Develop genetic medicines—safer, smarter, faster—for patients

Doctor cutting DNA molecule and check with analysis chromosome DNA genetic of human with ai virtual interface

How We Can Help

De-Risk Manufacturing

FormManufacturing™ combines two integrated services to reduce risk and cost from design through commercial release.

Design Vectors that Scale

FormSightAI™ screens thousands of vector designs in silico to identify high-performing candidates upfront, improving yield, reducing contaminants, & lowering COGS.

Defend Every Batch with Confidence

FormBatchQC™ delivers precise, lot-level insight into contaminants and comparability, so teams can defend every batch, streamline filings, and avoid surprises at inspection.

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“Form Bio’s AI-driven design platform is helping us rapidly evaluate and prioritize gene therapy constructs across multiple programs.”

Adrien Savy, PhD

Director Discovery Science, Coave Therapeutics

“Form Bio supports [Taysha’s] goals by providing us the data infrastructure support & analysis to be able to test samples in a streamlined way…”

Frederick Porter, PhD

Chief Technology Officer,  Taysha Gene Therapies

“Form Bio helps support [Solid’s] goals by allowing us to bring new therapeutics faster through an accelerated timeline to the clinic…”

Paul Herzich

Chief Technology Officer,  Solid Biosciences

Pipeline

Transforming the genetic medicine pipeline from concept to clinic with AI‑driven design and analysis

Indication

Partner

Discovery

Preclinical

IND

Clinical

Duchenne Muscular Dystrophy

Discovery

Preclinical

IND

Clinical

Limb Girdle Muscular Dystrophy Type 2G

Discovery

Preclinical

IND

Clinical

Alzheimer’s Disease

Discovery

Preclinical

IND

Clinical

Genome Engineering

The company Colossal Biosciences trusts to advance its genome engineering programs

How We Can Help

Next-Gen Editing Tools

Leverage breakthroughs in CRISPR and emerging genome engineering technologies to design and optimize precise genetic modifications in any genome.

AI-Powered Analysis

Combine AI-driven insights with expert biological interpretation to identify and validate key genotype-to-phenotype relationships to engineer desired traits.

Accelerate Validation

Validation analysis using amplicon or whole-genome sequencing to measure on-target efficiency and predict impactful off-target effects.

“Computer-aided design, fabrication, testing analysis & ML are key to the future of bioengineering . . . Form Bio is critical to pave the way.”

George Church, PhD

Professor, Harvard Medical School & MIT; Director of Synthetic Biology, The Wyss Institute

Animal Health

Unlock actionable genome insights for trait discovery, disease prevention & treatment, & breeding

3D illustration of a DNA double helix with a section of the strand breaking apart and highlighted in red, symbolizing gene editing or mutation.

How We Can Help

Gene Editing for Trait Enhancement

Optimize CRISPR, base, and prime editing strategies to improve editing efficiency, reduce off-target effects, and accelerate development of high-value traits.

Population Genomics Breeding

Analyze genomic variation across large populations to uncover trait associations, inform breeding decisions, and improve animal health and performance.

Integrated Data Management

Integrate genomic and phenotypic data to support disease surveillance, outbreak and pandemic response (e.g. avian influenza), and feed optimization.

Genomic QC & Characterization

Characterize on-target edits, off-target variants, and genomic changes across generations to support reproducibility, safety, and regulatory readiness.

Applications

Genome Assembly

Accurate reconstruction of genomes to drive discovery in genetics and biology

Genome Reconstruction

Piece together DNA fragments into accurate, contiguous sequences.

Downstream Insights

High quality assemblies that support variant detection, functional annotation, and comparative genomics.

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Genome Integrity Analysis

A clear, structured approach for characterizing genetic medicine

Drug Product Insights

Gain a clear view of what’s encapsidated— distribution of full vs. partial genomes and contaminated species.

Truncation Peaks

Mapping truncation hotspots to the vector map uncovers DNA complexities that can be mitigated through data-driven design.

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Codon Optimization

An innovative AI technology for reaching effective genetic sequences

Define Program Objectives

Clarify biological goals for optimization, such as boosting protein expression, enhancing manufacturability, and improving safety.

Balancing Tradeoffs

Our model aligns with your goals, optimizing across multiple objectives while managing tradeoffs like increasing expression vs. minimizing truncations.

Optimization & Insights

Leverage Form Bio’s proprietary FORMsight^AI model to optimize designs and identify codon substitutions that drive desirable outcomes.

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Solutions

Drug Substance Insights

Capsid Analysis

Bioinformatics Analysis

Gene Editing

AI Model Development

Manufacturing Intelligence

Interested in how our services can support your programs?

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About Form Bio

Form Bio, the first spinout from Colossal Biosciences (2022), expands foundational multi-species genome engineering technology into human genetic medicines.

We are AI and software engineers, bioinformaticians, molecular and cellular biologists, and drug developers dedicated to accelerating genetic medicine and unlocking breakthroughs that transform health and improve lives.