Generative Optimization

Enhance AAV Constructs for Ideal Dose Yield, Safety and Cost

FORMsightAI enables AAV gene therapy developers to optimize their constructs with improved properties, faster time to IND, and at reduced internal R&D costs.

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Find the Optimal Construct Blueprint for Your Therapy

Easily build the specific elements for your new construct, including the type of therapeutic gene, the promoter and enhancer sequences to control gene expression and viral vector.

Minimize Truncation Propensity

Leverage deep learning technology to minimize truncation propensity and improve reproducibility of the manufacturing process, reducing the potential for batch variability.

Maximize Predicted Full Reads

Apply FORMsightAI’s breakthrough machine learning models to improve predicted full reads and increase the consistency and quality of the therapeutic output.

End-to-End AI-Driven Analysis

Further algorithmic modeling, including codon optimization, CpG island detection and hairpin analysis, can predict likelihood of manufacturing success and cost efficiency.

Example Pre- and Post-Optimization Comparison of Truncation Propensities

Truncation Proportion illustration

Example Improvements On A Publicly Traded Gene Therapy Company’s AAV Construct


Learn how Form Bio can help optimize your vector design

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Key questions Form Bio can help answer

Scientist in lab

What is the truncation propensity of my candidate construct?

Which intron will optimize my construct’s safety?

What is the ideal molar ratio for my triple transfection?

Will my construct generate CpG islands?

Which promoter and other regulatory elements should I select?

Why isn’t my vector plasmid expressing as expected?

Unlock the Power of Form Bio’s Machine Learning for Game-Changing Benefits

FOrm Bio’s Machine Learning

Improve safety & dose yield by ensuring optimal capsid fill rate

Extend IP protection by filing fresh patents on optimized construct derivatives

Reduce costs by avoiding expensive bioreactor runs on suboptimal constructs

Save time by reducing the number of test manufacturing cycles for a therapeutic candidate

FORMsightAI models undergo continuous validation with biological studies conducted with independent lab partners and CDMOs.

More Capabilities to Accelerate Your Cell & Gene Therapy R&D Journey

Comparative Analysis

Compare an array of
constructs with different design characteristics to find the most promising versions

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Product Characterization

Fully understand constructs with automated AAV characterization reporting

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Biomanfuacturing Simulation

Predict manufacturing results relating to truncations and other issues

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Get Your Therapeutic Candidate to Market Faster

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