Explore Your AAV Vector Design Space
Design for Safety
Numerous studies have shown immunogenicity of empty capsids in humans (ref 1 & 2). Researchers have several avenues to reduce the innate immunogenicity of vector plasmids. Form Bio facilitates in silico vector design iterations to enhance drug safety by minimizing empty and partial capsids, predicting CpG islands, assessing truncation propensity and evaluating secondary and tertiary structures—thus mitigating adaptive immune responses.